4th Year MBBS Pathology (Special Pathology) OSPE by UHS (Set-5)

Following are the OSPE papers (Set-5) of 4th year MBBS Special Pathology UHS with  Answers/Keys.

 1.Ulcerative colitis : The pale irregular regions comprise ulcerations, n there is also pseudopolyp formations.


2.UC involve rectum , sigmoid n may involve entire colon  

1. Myocardial Infarct 

2. factors: occlusion of an artery (atherosclerosis) , thrombosis, embolus, smoking, age, sex, etc 

3. At 5hrs-early coagulative necrosis, edema, hemorrhage

‎1- Fatty Streak 
2- atherosclerotic plaque penetrate the intramycardial branches of coronary arteries n severe occlusion leads mycordial injury. 3- it composed of cells inlude SMCs, macrophages n Tcells . ECM include collagen , elastic fiber n proteoglycans, Intracellular n extracellular lipids . Superficial layer is Fibrous cap n deep to it is necrotic core 

 ‎1. Paget cells which are highly eosionphilic

2. DCIS, Invasive ductul carcinoma
3. Hergulin produced by keritanocytes act on cancer cells and they convert iinto paget cells, these paget cells go to the skin withut disrupting the basement membrane , disrupt the epitheilum and hence edema and oozing occurs 

1.MPGN 
2.Immunofluorescence staining3.three types : Minimal change, rapid progressive n membranous 

  ‎1 ) -single layer of Tall columnar epithelium , they are ciliated n some part are dome shaped secretary cells .

- Psommoma bodies 
2) Serous type 
3) Mucinous n endometroid

  ‎1- seminoma cells : large , round to polyhydral cells wth distinct cell membranes , clear cytoplasm n central round nuclei with infrequent mitosis 

2- Seminoma 
3- Non differentiated totipotential germ cell tumor

  ‎1- Disruption of thyroid follicles , with extravasation of colloid leading to a PMN infiltrate. 

2- subacute granulomatous thyroiditis 
3- viral infection

  ‎1- Gaint cell tumor of bone 
2- benign 

3- Soap bubble appearence. 
4-Reactive macrophages n mononuclear celss

 ‎1-honeycomb appearence

2- Interstitial pneumonia, non-specific interstitial pneumonia, pneumoconiosis 
3-Interstitium 

1. Polcythemia vera 

2. bone marrow biopsy n JAK2 mutation 

3. erythropoitin level will b low

 1. Obstructive jaundice

2. ALP, GAMMA GT, BILIRUBIN
3. ALT, AST, LDH
4. ALBUMIN

1.less than 3.5 gm/day urinary protien in nephritic syndrome

2. hyperlipidemia, hypoalbuminemia, lipiduria, oedema, protienuria

3. low but not as low as in nephrotic syndrome

1. Grave's Diesease

2. TSH

1. Papillary carcinoma of thyroid gland

2. Multifocal, cystic and contain papillary excresences

3. Formalin

 1. ALL

2. Giemsa
3. sudan black stain.
4. condensed nuclear chromatin, small nucleoli, agranular scant cytoplasm 

 ‎1. Meningioma
2. Mass attached to dura and indenting brain, m/e will show psammoma bodies and cells in whorls
3. Meningiothelial cells of arachnoid

 1. Peptic ulcer

2. hemorrhage, perforation

3. Zollinger Ellison syndrome

‎1. gastric antrum
2. gastric ca confined to mucosa and submucosa regardless of lymph node involvement
‎3- Sister Mary Joseph nodule (node) is the palpable nodule buldge into umbilicus due to metastasis of gastric Ca, colonic Ca or pancreatic Ca