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Pathology Slides Presentation by Sir Asghar Javaid

SPECIAL THANKS to DR. NABEEL AKHTAR (N-57) for contibuting this Presentation
May Allah Bless him. Ameen!

You can also contribute any help stuff by contacting me directly or by mailing me at aeymon[at]live[dot]com.

Adjust size: The images have been sized for appropriate reading. But if you want to change the size, 
hold Ctrl then press + to increase or to decrease the size.


 This karyotype of 46, XY, t(8;14) demonstrates the translocation typical for a Burkitt type (small non-cleaved) lymphoma
 
 Burkitt lymphoma. A, At low power, numerous pale tingible body macrophages are evident, producing a "starry sky" appearance.
 
 B, At high power, tumor cells have multiple
small nucleoli and high mitotic index. The lack of significant variation in nuclear shape and size lends a monotonous appearance. (B, courtesy of Dr. José Hernandez, Department of
Pathology, University of Texas Southwestern Medical School, Dallas, TX.)
 Follicular lymphoma (lymph node). A, Nodular aggregates of lymphoma cells are present throughout lymph node.
 
 B, At high magnification, small lymphoid cells with
condensed chromatin and irregular or cleaved nuclear outlines (centrocytes) are mixed with a population of larger cells with nucleoli (centroblasts). (A, courtesy of Dr. Robert W.
McKenna, Department of Pathology, University of Texas Southwestern Medical School, Dallas, TX.)
 Diffuse large B-cell lymphoma. Tumor cells have large nuclei, open chromatin, and prominent nucleoli. (Courtesy of Dr. Robert W. McKenna, Department of Pathology,
University of Texas Southwestern Medical School, Dallas, TX.)
 diagnosis is: malignant lymphoma, small lymphocytic type, diffuse
 
 This is a malignant lymphoma, small cleaved cell type, follicular (also known as: malignant lymphoma, poorly differentiated lymphocytic type, nodular).
 
 The malignant lymphocytes here are very large with a moderately abundant cytoplasm, and the nuclei are round to ovoid with prominent nucleoli and occasional mitoses. The diagnosis is diffuse malignant lymphoma, large cell type (also known as: immunoblastic lymphoma).
 
 The cells are large, with prominent nucleoli and abundant cytoplasm
large cell lymphomas 
 Diagnostic Reed-Sternberg cell, with two nuclear lobes, large inclusion-like nucleoli and abundant cytoplasm, surrounded by lymphocytes, macrophages, and an eosinophil
 B, Reed-Sternberg cell, mononuclear variant
 C, Reed-Sternberg cell, lacunar variant.
 D, Reed-Sternberg cell, lymphohistiocytic (L&H) variant
  Hodgkin lymphoma, mixed cellularity type
 This is Hodgkin's disease, nodular sclerosis type. Note the bands of pink collagenous tissue dividing the field.
 
 Hodgkin lymphoma, nodular sclerosis type
 nodular sclerosing Hodgkin's disease has prominent bands of fibrosis

 the lacunar cells characteristic for the nodular sclerosis type of Hodgkin's disease.
 
 Hodgkin lymphoma, lymphocyte predominance type
 large cells with large, pale nuclei containing large purple nucleoli at the arrowheads. These are Reed-Sternberg cells
 
 With antibody to CD-15, this immunoperoxidase stain demonstrates the Reed-Sternberg and lacunar cells characteristic for Hodgkin's disease
 

 CML
 CML

 Myeloid cells of CML are also characterized by the Philadelphia chromosome (Ph1) on karyotyping. This is a translocation of a portion of the q arm of chromosome 22 to the q arm of chromosome 9, designated t(9:22).


 Cml spleen


 A, Nucleated red cell progenitors with multilobated or multiple nuclei


 B, Ringed sideroblasts, erythroid progenitors with iron-laden mitochondria, seen as blue perinuclear granules (Prussian blue stain) 
 C, Pseudo-Pelger-Hüet cells, neutrophils with only two nuclear lobes instead of normal three to four, are observed at the top and bottom of this field
D, Megakaryocytes with multiple nuclei instead of the normal single multilobated nucleus. (A, B, D, marrow aspirates; C, peripheral blood smear.)


 AML
 acute myelogenous leukemia is seen here. There is one lone megakaryocyte at the right center 

 Acute promyelocytic leukemia (FAB M3 subtype)
 Acute monocytic leukemia (FAB M5b subtype)
 CLL

  NORMAL BONE MARROW
 CLL

 Anaplastic large cell lymphoma. A, Several "hallmark" cells with horseshoe-like or "embryo-like" nuclei and abundant cytoplasm lie near the center of the field
 . B,
Immunohistochemical stain demonstrating expression of ALK protein. (Courtesy of Dr. Jeffrey Kutok, Department of Pathology, Brigham and Women's Hospital, Boston, MA.)




 BENIGN THYMOMA
 MALIGNANT THYMOMA
 Mantle cell lymphoma. A, At low power, neoplastic lymphoid cells surround a small, atrophic germinal center, exhibiting a mantle zone pattern of growth.
 
 B, High-power
view shows a homogeneous population of small lymphoid cells with somewhat irregular nuclear outlines, condensed chromatin, and scant cytoplasm. Large cells resembling
prolymphocytes (seen in chronic lymphocytic leukemia) and centroblasts (seen in follicular lymp

Lymphoplasmacytic lymphoma. Bone marrow biopsy shows a characteristic mixture of small lymphoid cells exhibiting various degrees of plasma cell differentiation. In
addition, a mast cell with purplish-red cytoplasmic granules is present at the left-hand side of the field.


BCL2 expression in reactive and neoplastic follicles. BCL2 protein was detected by using an immunohistochemical technique that produces a brown stain. In reactive
follicles (A), BCL2 is present in mantle zone cells but not follicular center B cells, whereas follicular lymphoma cells (B) exhibit strong BCL2 staining 

4 COMMENTS:

Saliha said...

Thank you for such nice work!

Anonymous said...

Thanks alot for being so concerned for your students
you have proved of being a teacher who can really understand the difficulties of students.

Anonymous said...

thnxxxxxx alot dr,itz really a great effort...keep it up...allah bless you alwayz ameeeeeeeeeeeeeeeeeeen;-]

Anonymous said...

most ov them are 4 postgraduate level..:P..